Marginalization, Vulnerability and Economic Dynamics in COVID-19

Abstract COVID-19, caused by the coronavirus family SARS-CoV-2 and declared a pandemic in March 2020, continues to spread. Its enormous and unprecedented impact on our society has evidenced the huge social inequity of our modern society, in which the most vulnerable individuals have been pushed into even worse socioeconomic situations, struggling to survive. As the pandemic continues, we witness the huge suffering of the most marginalized populations around the globe, even in developed, high-income latitudes, such as North America and Europe. That is even worse in low-income regions, such as Brazil, where the public healthcare infrastructure had already been struggling before the pandemic. Cities with even more evident social inequity have been impacted the most, leaving the most socioeconomically disadvantaged ones, such as slum residents and black people, continuously inflating the statistics of COVID-19 sufferers. Poverty, marginalization, and inequity have been well-known risk factors for morbidity and mortality from other diseases. However, COVID-19 has deepened our society's wound. It is up to us to heal it up. If we really care for the others and want to survive as a species, we must fight social inequity.


Introduction
One of the most disastrous diseases in human history, COVID-19, caused by the coronavirus family SARS-CoV-2, continues to spread across the world, after being declared pandemic by the World Health Organization on March 11, 2020, causing 2 486 405 deaths worldwide. 1 The rapid spread and high estimated infectivity of SARS-CoV-2 coupled with the illness severity have led to widespread shuttering of businesses and implementation of mandatory stay-at-home orders around the world, in addition to a global economic shutdown. 2 The dynamics between health and inequity has been regularly present for marginalized populations worldwide. The desperate measures to stop the virus spread have had an economic impact on the most vulnerable countries and communities. 3 Known before the current pandemic, a study extending from 1950 to 1991 and involving 20 developed, developing and underdeveloped countries, has revealed that the increasing prevalence of infectious diseases will not only increase human mortality and morbidity, but will result in the gradual erosion of the state capacity and increase poverty. 4 The disease-induced economic decline has been found to have a negative effect on the capacity to manage financial resources, resilience, the search for responses, autonomy and legitimacy. 5 Even before the COVID-19 pandemic, the balance between inequity and health has been in turmoil, with the most marginalized populations around the world being the most impacted. 6 Currently, an important portion of those populations has been forced even deeper into poverty. Among other factors, this is the result of a historic confluence of social, structural, and economic inequity. 7 In this phenomenon, informal workers and unemployed ones are greatly affected, and this is compounded by their precarious backgrounds. 8,9 The aggressiveness of the new virus took the international community by surprise and drove different healthcare systems in different latitudes to a nearly complete collapse.
Even highly developed countries, like the United States of America (USA), one of the biggest economies in the globe, has struggled to give its citizens the appropriate care they desperately need; and sadly, people affected by COVID-19 are counted by millions. 11 The disease-related complications, rates of hospitalization and mortality are not homogeneous among the population, even within the same affected areas. New York City (NYC), with a population of 8 398 748 individuals and one of the most affected cities by the new disease, has evidenced a substantial variation in the rates of COVID-19 hospitalization and death across its boroughs. Bronx, which has the highest proportion of racial/ethnic minorities, most of them living in poverty, and the lowest levels of educational attainment, had higher rates of COVID-19-related hospitalization and death than the other four boroughs of NYC, including Manhattan, which has the highest population density but the lowest rates of hospitalization and death. 12 This phenomenon shows that not only the pathogen inner infective capability is important to its spread, but the social economical background of the community is of great importance for the viral spread dynamics. Early diagnosis and monitoring of patients with COVID-19 are critical to optimize individual outcomes and to prevent further community transmission. 11 In NYC, 34% and 28% of the deaths from COVID-19 occurred in Hispanic and black individuals, respectively, which represent only 29% and 22% of that city population; however, 27% of the deaths from COVID-19 occurred in white individuals, which represent 32% of the NYC population.
This phenomenon is more evident in African and Latin American latitudes, where many countries score poorly on the WASH Performance Index, which is a measure of access to abundant clean water and improved sanitation. If increased transmission due to fecal contamination is combined with climatically reduced contact transmission, the epidemiological dynamics of COVID-19 in Latin America may be fundamentally distinct from that currently observed in the Northern hemisphere. 13,14 The stay-at-home policies implemented worldwide are harder to apply to underdeveloped countries like those in Latin America. Policies, such as lockdown, have a great economic impact on the general population. In Brazil, the concept of remote work is not feasible for the great majority of the population. A local survey shows that only 27.1% of the population can work remotely, and this percentage represents people of high educational level, which in Brazil is scarce, reflecting and confirming the country's known social inequity. This scenario is even worse in the southeastern region of the country, which accounts for 42% of the Brazilian population and comprises some of the federal units with the highest demographic densities, such as São Paulo (166.23 pop/ km 2 ) and Rio de Janeiro (365.23 pop/km 2 ).
That population density and unique social dynamics have pushed the Brazilian Unified Public Health System (SUS) to its boundaries. The SUS, known as the world´s biggest social health care system with more than 200 million users, has almost faced a collapse with the current pandemic. 15,16 The city of Rio de Janeiro, known for its great social status breaches, has been one of the most affected. There, hospitals have been challenged to almost their healthcare limits because of the high number of patients in need for inpatient/intensive care. 17 Some of the greatest threats faced by healthcare workers treating COVID-19 patients are the various difficulties of patients' access to medical institutions. In Rio de Janeiro, on average, those patients live in the city's periphery, have a low income, and, inside their own communities, deep in the slums, they have to cope with violence and segregation, in addition to a great limitation of public transportation. In our personal experience, we have seen that low baseline economic status is related to in-hospital complications and can influence in-hospital mortality. 18,19 These markers of marginalization, among others, are determinants of the individual outcomes related to different clinical and social scenarios.
Marginalized communities are those excluded from mainstream social, economic, educational, and/ or cultural life. Examples of marginalized populations are groups excluded due to race, sexual orientation, age, language, physical ability, and/or immigration status. Marginalization occurs due to unequal power relationships between social groups. 9 As portrayed by Rogers, "there is a distinction between inherent vulnerability, arising from one's corporeality; situational vulnerability stemming from one's personal, social, political, economic, or environmental situatedness as an individual or member of a group; and pathogenic vulnerability, emerging in sociopolitical contexts, where a pre-existing vulnerability is multiplied by oppression or injustice". 20,21 V u l n e r a b l e g r o u p s o f p e o p l e a r e t h o s e disproportionally exposed to risk, but the composition of such groups change dynamically. 22 A person not considered vulnerable at the outset of the pandemic can become vulnerable depending on the policies adopted. The risks of sudden loss of income or of access to social support have consequences difficult to estimate; in addition, identifying all those who might become vulnerable is a challenge. 23 Populations are heterogeneous in composition (for example, those living with disability, people living in poverty, and racial, ethnic, sexual and gender minorities), and the intersection of those identities within an individual or group can further compound their baseline disadvantage. 24 When analyzing the environmental factors of those communities, African Americans are 75% more likely to reside in proximity to a polluting facility, like a factory or refinery, than other Americans, and, as compared to white individuals, they are exposed to a 38% more polluted air. 25 Even biological risk factors for COVID-19, such as hypertension, diabetes, asthma, and obesity, can reflect environmental and sociological precipitating and contributing factors, as much as racial differences in biology. 26 Cardiovascular diseases (CVD), such as hypertension and myocardial infarction, are well known to be related to COVID-19 mortality and its complications. In addition to those comorbidities, the outcome is compounded by one's socioeconomic status and even local community. 27 Among the various minority population groups, black men have the highest overall death rate from CVD, which extends to black women, whose death rates from CVD are higher than those of white women. 28 In addition, individuals of Hispanic or Latino ancestry in the USA have the highest incidence of nonalcoholic fatty liver disease. 29 International evidence has shown that marginalized groups are much more likely to be infected and subsequently die from COVID-19. 30 Three groups have disproportionately suffered the health burden: ethnic minorities; the socioeconomically disadvantaged; and the elderly. 31 The first two groups are highly prevalent in Brazil, inflating the socioeconomic challenge in our country, making it even more vulnerable to the current phenomenon. 32,33 The COVID-19 pandemic has evidenced a well spread phenomenon. Social inequity is a fact of the modern world, a consequence of wealth imbalance, and has recently become even deeper in our society. The current pandemic has only shown its already multifactorial disastrous effects on humankind. (Figure 1)

References
As with every crisis, we have the opportunity to learn. The world's biggest challenge today is not only to fight back the virus, but to better understand our particular conditions as humans. We have to fight as one, and we must recognize that social inequity not only destroys the most vulnerable members of our society but helps make our society more primitive.
The COVID-19 has managed to threaten the very existence of our society as we know it today, but the real risk behind the pandemic is the social illness. Marginalization, inequity, and racism are the real threats, and they require immediate attention and solutions. To have better results, let us not wait the next pandemic to start tackling the real issues affecting us globally. It is time to lose our chains!

Potential Conflict of Interest
No potential conflict of interest relevant to this article was reported.

Sources of Funding
There were no external funding sources for this study.

Study Association
This article is part of the thesis of Cardiology master in Science submitted by Andres Felipe Valencia Rendon, from Universidade Federal do Rio de Janeiro.