International Journal of Cardiovascular Sciences. 18/nov/2020;33(6):637-47.
The Clinical Course of Takotsubo Syndrome Diagnosed According to the InterTAK Criteria
Nelson Henrique Fantin Fundão
, Henrique Barbosa Ribeiro
, Carlos de Magalhães Campos
, Vinicius Bocchino Seleme
, Alexandre de Matos Soeiro
, Marcelo Luiz Campos Vieira
, Wilson Mathias Jr
, Ludhmilla Abraão Hajjar
, Expedito E. Ribeiro, Roberto Kalil Filho
Abstract
Background
There has been an increase in the number of cases of Takotsubo syndrome (TTS) and of scientific publications on the theme over the last years. However, little is known about the status of this disease in Brazilian hospitals.
Objective
To assess mortality and major adverse cardiovascular events (MACE) during hospitalization and follow-up of TTS patients seen in a tertiary hospital in Brazil.
Methods
This was a retrospective, observational study on 48 patients. Clinical data, signs and symptoms, complementary tests, MACE and all-cause mortality were assessed on admission and during follow-up. Kaplan-Meier curves were used for analysis of all-cause mortality and risk for MACE at median follow-up. The 95% confidence interval was also calculated for a significance level of 5%.
Results
Mean age of patients was 71 years (SD±13 years), and most patients were women (n=41; 85.4%). During hospitalization, four patients (8.3%) died and five (10.4%) developed MACE. At median follow-up of 354.5 days (IQR of 81.5-896.5 days), the risk of all-cause mortality and MACE was 11.1% (95% CI= 1.8-20.3%) and 12.7% (95% CI= 3.3-22.3%), respectively.
Conclusion
TTS was associated with high morbidity and mortality rates in a tertiary hospital in Brazil, which were comparable to those observed in acute coronary syndrome. Therefore, the severity of TTS should not be underestimated, and new therapeutic strategies are required. Int J Cardiovasc Sci. 2020; [online].ahead print, PP.0-0
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